Hewlett Packard Enterprise has unveiled major enhancements to its NVIDIA AI Computing by HPE portfolio, delivering enterprise-grade solutions that support organizations of all sizes throughout the entire AI lifecycle. These updates strengthen integration with NVIDIA AI Enterprise, introduce the latest NVIDIA AI models and NVIDIA Blueprints into HPE Private Cloud AI, and pave the way for streamlined AI application deployment.
A key highlight is the upcoming availability of HPE ProLiant Compute servers featuring NVIDIA Blackwell accelerated computing designed to power generative, agentic, and physical AI workloads at scale.
Next-Generation HPE ProLiant Servers with NVIDIA Blackwell Architecture
The HPE ProLiant Compute portfolio will soon include configurations accelerated by NVIDIA RTX PRO 6000 Blackwell GPUs, offered in two new server models:
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HPE ProLiant DL385 Gen11 – Supports up to two NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs in a compact 2U RTX PRO Server form factor. Air-cooled and datacenter-ready, it’s ideal for enterprises tackling growing AI demands.
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HPE ProLiant DL380a Gen12 – Accommodates up to eight NVIDIA RTX PRO 6000 GPUs in a 4U form factor, with shipments beginning in September.
Built for performance, scalability, and enterprise security, these servers feature HPE Integrated Lights Out (iLO) 7 Silicon Root of Trust and quantum-resistant firmware signing. Centralized, cloud-native automation through HPE Compute Ops Management can reduce IT management time by up to 75% and cut downtime by 4.8 hours per server annually.
Target use cases include generative and agentic AI, robotics, industrial automation, autonomous vehicles, simulation, 3D modeling, digital twins, visual computing, and enterprise applications.
Also Read: Oxmiq Labs™: Rebuilding the GPU Stack from Atoms to Agents
Advancing HPE Private Cloud AI with NVIDIA Models and Blueprints
HPE also announced that the next generation of HPE Private Cloud AI, co-developed with NVIDIA, will launch later this year. This update will support NVIDIA RTX PRO 6000 GPUs with seamless scalability across GPU generations, enhanced air-gapped management, and enterprise-grade multi-tenancy.
The platform will incorporate the latest NVIDIA Nemotron models for agentic AI, the Cosmos Reason vision-language model for robotics and physical AI, and the NVIDIA Blueprint for Video Search and Summarization (VSS 2.4), enabling advanced AI agents for extracting insights from massive video datasets.
Through deep integration with NVIDIA AI accelerated computing, networking, and software, HPE Private Cloud AI offers enterprises rapid deployment of NVIDIA NIM microservices and access to NVIDIA Blueprints via HPE AI Essentials helping organizations accelerate AI production while retaining full control over their data.
Executive Perspectives
“Our collaboration with NVIDIA continues to push the boundaries of innovation, delivering solutions that unlock the value of generative, agentic and physical AI while addressing the unique demands of enterprise workloads,” said Cheri Williams, Senior Vice President and General Manager for private cloud and flex solutions at HPE.
“HPE is committed to empowering enterprises with the tools they need to succeed in the age of AI,” Williams added. “With the combination of HPE ProLiant servers and expanded capabilities in HPE Private Cloud AI, we’re enabling organizations to embrace the future of AI with confidence and agility.”
Justin Boitano, Vice President of Enterprise AI at NVIDIA, commented: “Enterprises need flexible, efficient infrastructure to keep pace with the demands of modern AI. With NVIDIA RTX PRO 6000 Blackwell GPUs in HPE’s 2U ProLiant servers, enterprises can accelerate virtually every workload on a single, unified, enterprise-ready platform.”
