PhenoScope can cut drug development time and costs significantly, while delivering safer & more effective therapy for cancer patients
SimBioSys, a leading innovator in precision oncology, and General Inception (“GI”), a global company Igniter, announced a strategic partnership that aims to significantly reduce oncology drug development times and cut development costs by using AI and biophysical modeling to better understand unique tumor spatial biophysical characteristics.
PhenoScope, SimBioSys’ powerful proprietary technology and service, can analyze vast fields of multi-modal data seamlessly, generating novel insights, including unique spatial biophysical insights in 4-dimension space, for cancer drug discovery and development which are not apparent by looking at one type of data alone. Drawing on SimBioSys’ data of more than 12,000 individual cancer patient profiles in 33 solid cancers, and a virtual tumor bank of more than 20,000 spatially resolved tumors, equivalent to more than 100 terabytes of proprietary data, PhenoScope can be used in drug development to predict personalized patient response over time, including drug binding and metabolic response, as well as dosing capabilities across every scenario and delivery.
GI, founded in 2020, is a venture studio with a portfolio of over 40 companies, 10 of which are therapeutics, to which it expects to add up to eight new therapeutics every year for the next five years.
PhenoScope will enable a deep phenotyping of tumor biology and identification of sets of biomarkers with high predictive value, providing a varied toolkit that is useful across the whole spectrum of drug development, from spotting novel biomarkers for new drugs, to identifying the patients most likely to benefit, to guiding on indication selection and combination selection, to identifying the likely optimal therapeutic dose before a clinical trial starts – known as ‘precision dosing’.
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Better patient dosing will not only increase efficacy but most importantly reduce unwanted side effects that impact that patient significantly and add costs to the healthcare system. The growing importance of this is reflected in the US Food and Drug Administration’s Oncology Center of Excellence’s Project Optimus, an initiative to reform dose optimization and dose selection paradigms in oncology drug development.
The level of drug development in oncology is intense, with more than 2,000 products currently under development and drug trial starts up 22% in 2022 compared to 2018. Emerging biopharma companies account for 71% of this pipeline. Spending on cancer medicines is expected to reach $375Bn globally by 2027, up from $196Bn in 2022.1
Venkat Reddy, Chief Scientific Officer of General Inception, said:
“This collaboration marks a significant milestone in the pursuit of more effective, personalized cancer therapies, as all new oncology drug incubations under General Inception will be able to use SimBioSys’ state-of-the-art PhenoScope platform and drug development services. More efficient target identification, credentialing, and clinical positioning will significantly reduce the time it takes to get to the clinic and improve efficacy through patient stratification, precision medicine approaches, and other means. Under this agreement, General Inception’s incubated companies will have the ability to accelerate their pipelines thanks to these advanced capabilities.”
Tushar Pandey, Chief Executive Officer of SimBioSys, said:
“Together, we are committed to introducing much-needed precision to the drug development process. By partnering with General Inception, we can cut their oncology drug development time and costs significantly. Not only will that reduce program costs but also increase efficacy and reduce patient side effects through better dosing. This strategic relationship not only underscores our commitment to innovation in the fight against cancer but also promises to deliver groundbreaking precision oncology drugs to patients faster than ever before.”
SOURCE: BusinessWire